Climacterium, climacteric disturbance and rejuvenation of sex center.

No one would object to the proposition that climacterium means the stage of incipient senility, but there are few works giving more concrete attention to it. It is also generally accepted that climacterium begins when the ovary begins to show signs of senescence, but no one has proved it and it is not yet known whether this hypothesis is tenable. The cases of sundry climacteric disturbances are attributed to a "deficiency of ovarian hormones", but we feel justified in raising questions against this generalization. The present authors have been engaged in making researches to solve such questions on climacterium and cli macteric disturbances for the past 10 years. In the following, the results of these studies are presented, together with a discussion on the relief from climacterium, that is, rejuvenation of the sex center.